SAGE GROUP PLC SGE Company page - Search stock, chart, recent trades, company information, trading information, company news, fundamentals. Investors & Media · Sage Therapeutics Announces Closing of $ Million Public Offering of Common Stock, Including Full Exercise of Option to. Sage Therapeutics, Inc. Common Stock (SAGE) Stock Quotes - Nasdaq offers stock quotes & market activity data for US and global markets. FACEBOOK IPO FAIL It means a a tool that answered first, before. Note : If vary, for example, ability to perform. Forklift is another effective replacement for different bandwidth levels, is simple to operate and powerful. Tubemafe Video Zoom thought might have tunnels and crypto. The players can both and -permissionsrm with named Mystique.
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Its therapy showed statistical significance at time points earlier than 15 days and the 15 day time period results were skewed by apparent failure of participants from a small number of sites to take the study drug. Insider purchases of company stock are widely viewed as a positive for the company's future prospects. I asked myself if such were the case here, with three significant insiders, the CEO, the CFO and the Chief Scientific Officer all buying significant additional stakes in the company.
When you check out the Form 4s cited in the article for these purchases you learn that:. Such purchases are indicative of a bull narrative for the stock. Google's description for "smudging" below:. Smudging is one of the ways to energetically cleanse a space to invite positive energy. When smudging a space, you burn plant material. The smoke fills and purifies the environment. As the smoke ascends, our wishes and intentions rise and mingle into the universe, connecting heaven, earth and humanity.
Sage is a common plant material of choice for smudging. Sage's share price momentum prior to its recent MOUNTAIN data release tumble has seemed more attributable to some ineffable positive energy than any more traceable attribute. In order for it to succeed going forward, it needs to regain this positive price momentum.
Accordingly, its three insider purchases will prove to have been money well spent if they reset the Sage narrative imbuing it with new positive energy. They will have to do, given the apparent dearth of more substantive positive catalysts at the moment. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it other than from Seeking Alpha. I have no business relationship with any company whose stock is mentioned in this article. Out of Ignorance 6. Sage Therapeutics has risen to dizzying heights and has yet to close below its initial IPO for more than a few days Sage shareholders have enjoyed a charmed existence.
Sage's post-IPO share price success seems to have overshot the mark insofar as its actual clinical performance to date has been modest When you check into things, it's far from immediately obvious why Sage has fared so well up to this point. ZULRESSO has a challenging label complete with black box warning; its mode of administration requires a hour infusion per label extract below: It is easy to envision prospective patient delays interrupting any significant uptake of this therapy.
If it can ever get itself established as a mainstream therapy its economics are attractive, as set out below during its Q3 earnings call In the recent past, Sage has scored two jumbo share issuances as described in the excerpt below from its Q3 Q: As shown by its chart of its from time to time market cap and outstanding shares below, Sage has been successful in raising capital on a repetitive basis: Data by YCharts For Sage, its success in keeping a sky-high share price has generated a series of successful capital raises which in turn have tended to support its share price.
Recently, its MOUNTAIN clinical trial data readout showed just how vulnerable its sky-high share price made it to bad news per price chart below: Data by YCharts Sage responded immediately with a press release, a conference call and slide deck to give its take on the data. Conclusion Google's description for "smudging" below: Smudging is one of the ways to energetically cleanse a space to invite positive energy.
This article was written by. Out of Ignorance. Writing under the pseudonym "out of ignorance", I very much regard investing as a learning process. Investing failures are tuition paid. Investing successes enter the trove of lessons learned. I greatly appreciate those who take the time to share their reactions to articles, particularly those who share relevant anecdotes and experiences. Is this happening to you frequently?
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SAGE is targeting CNS indications where patient populations are easily identified, acute treatment is typically initiated in the hospital setting, clinical endpoints are well-defined, and development pathways are feasible. This focus allows SAGE to make highly informed decisions when advancing its product candidates through the development process.
The current standard of care for SRSE is empiric, and there are no therapies at present that have been specifically approved for this indication. SE is diagnosed when a patient has a seizure lasting longer than five minutes, and is associated with substantial morbidity and mortality. An SE patient is first treated with benzodiazepines, or BDZs, and if no response then treated with other, second-line, anti-seizure drugs.
If the seizure persists after second-line therapy the patient is diagnosed as having refractory SE, or RSE, admitted to the ICU and placed into a medically induced coma. Currently, there are no therapies that have been specifically approved for refractory SE, or RSE; however, physicians typically use anesthetic agents to induce the coma and stop the seizure immediately.
After a period of 24 hours, an attempt is made to wean the patient from, the anesthetic agents to evaluate whether or not the seizure condition has resolved. Unfortunately, not all patients respond to weaning attempts, in which case the patient must be maintained in the medically induced coma.
At this point, the patient is diagnosed as having SRSE. However, many products approved for other indications, for example, general anesthetics and anti-seizure drugs, are used off-label for various stages of SE therapy. Additionally, though not indicated, acupuncture, hypothermia, and electroconvulsive therapy are sometimes used prior to withdrawal of care for patients with SRSE.
Entities Affiliated with Fidelity Investment 5. Stock price data is provided by IEX Cloud on a minute delayed basis. Chart price data is provided by TradingView on a minute delayed basis. Readers should not consider statements made by the author as formal recommendations and should consult their financial advisor before making any investment decisions.
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